Ablation of p21-Activated Kinase-1 in Mice Promotes Isoproterenol-Induced Cardiac Hypertrophy in Association with Activation of Erk1/2 and Inhibition of Protein Phosphatase 2A

RATIONALE: Earlier investigations in our lab indicated an anti-adrenergic effect induced by activation of p21-activated kinase (Pak-1) and protein phosphatase 2A (PP2A). OBJECTIVE: Our objective was to test the hypothesis that Pak-1/PP2A is a signaling cascade controlling stress-induced cardiac grow...

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Main Authors: Taglieri, Domenico M., Monasky, Michelle M., Knezevic, Ivana, Sheehan, Katherine A., Lei, Ming, Wang, Xin, Chernoff, Jonathan, Wolska, Beata M., Ke, Yunbo, Solaro, R. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208757/
https://ncbi.nlm.nih.gov/pubmed/21971074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.09.016
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