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Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema
The pathogenesis of neuromyelitis optica (NMO) involves binding of IgG autoantibodies (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system (CNS). We studied the in vivo processing in mice of a recombinant monoclonal human NMO-IgG that binds strongly to mouse AQP4. Following in...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2011
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208637/ https://ncbi.nlm.nih.gov/pubmed/22076159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027412 |
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