Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induced obesity. Hence, DGAT1 is considered a potential...

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Hlavní autoři: Enayetallah, Ahmed E., Ziemek, Daniel, Leininger, Michael T., Randhawa, Ranjit, Yang, Jianxin, Manion, Tara B., Mather, Dawn E., Zavadoski, William J., Kuhn, Max, Treadway, Judith L., des Etages, Shelly Ann G., Gibbs, E. Michael, Greene, Nigel, Steppan, Claire M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208573/
https://ncbi.nlm.nih.gov/pubmed/22073239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027009
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