Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccinations: implications for clinical trials design

PURPOSE: Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Clinical trials for GBM using dendritic cell (DC) vaccination resulted in anti-tumor immune responses. Herein we tested the hypothesis that combining in situ (intratumoral) Ad-Flt3L/Ad-TK-mediated gene therapy with DC vaccinatio...

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Bibliographic Details
Main Authors: Mineharu, Yohei, King, Gwendalyn D., Muhammad, AKM G., Bannykh, Serguei, Kroeger, Kurt M., Liu, Chunyan, Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208508/
https://ncbi.nlm.nih.gov/pubmed/21632862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0915
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