TAK-701, a humanized monoclonal antibody to HGF, reverses gefitinib resistance induced by tumor-derived HGF in non–small cell lung cancer with an EGFR mutation

PURPOSE: Most non–small cell lung cancer (NSCLC) tumors with an activating mutation of the epidermal growth factor receptor (EGFR) are initially responsive to EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib but ultimately develop resistance to these drugs. Hepatocyte growth factor (HGF) ind...

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Detalhes bibliográficos
Main Authors: Okamoto, Wataru, Okamoto, Isamu, Tanaka, Kaoru, Hatashita, Erina, Yamada, Yuki, Kuwata, Kiyoko, Yamaguchi, Haruka, Arao, Tokuzo, Nishio, Kazuto, Fukuoka, Masahiro, Jänne, Pasi A., Nakagawa, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208321/
https://ncbi.nlm.nih.gov/pubmed/20716641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0481
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