TAK-701, a humanized monoclonal antibody to HGF, reverses gefitinib resistance induced by tumor-derived HGF in non–small cell lung cancer with an EGFR mutation

PURPOSE: Most non–small cell lung cancer (NSCLC) tumors with an activating mutation of the epidermal growth factor receptor (EGFR) are initially responsive to EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib but ultimately develop resistance to these drugs. Hepatocyte growth factor (HGF) ind...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Okamoto, Wataru, Okamoto, Isamu, Tanaka, Kaoru, Hatashita, Erina, Yamada, Yuki, Kuwata, Kiyoko, Yamaguchi, Haruka, Arao, Tokuzo, Nishio, Kazuto, Fukuoka, Masahiro, Jänne, Pasi A., Nakagawa, Kazuhiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208321/
https://ncbi.nlm.nih.gov/pubmed/20716641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0481
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