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Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates uPA/uPAR-Dependent Activation of TGF beta and Potentiates Fibrosis
In congenital heart block (CHB), binding of maternal anti-SSA/Ro antibodies to fetal apoptotic cardiocytes impairs their removal by healthy cardiocytes and increases uPA/uPAR-dependent plasmin activation. Since the uPA/uPAR system plays a role in TGF beta activation, we evaluated whether anti-Ro bin...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208032/ https://ncbi.nlm.nih.gov/pubmed/22013113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101288 |
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