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A Switch from Canonical to Noncanonical Wnt Signaling Mediates Drug Resistance in Colon Cancer Cells

Butyrate, a fermentation product of fiber in the colon, acts as a histone deacetylase inhibitor (HDACi) and induces apoptosis in colon cancer (CC) cells in vitro. We have reported that the apoptotic effects of butyrate are dependent upon the hyperactivation of the Wnt/beta-catenin pathway. However,...

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Bibliographic Details
Main Authors: Bordonaro, Michael, Tewari, Shruti, Cicco, Catherine E., Atamna, Wafa, Lazarova, Darina L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207861/
https://ncbi.nlm.nih.gov/pubmed/22073312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027308
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