Translational Suppression of Atrophic Regulators by MicroRNA-23a Integrates Resistance to Skeletal Muscle Atrophy

Muscle atrophy is caused by accelerated protein degradation and occurs in many pathological states. Two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and muscle RING-finger 1 (MuRF1), are prominently induced during muscle atrophy and mediate atrophy-associated protein degradation. Blocking the...

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Detalhes bibliográficos
Main Authors: Wada, Shogo, Kato, Yoshio, Okutsu, Mitsuharu, Miyaki, Shigeru, Suzuki, Katsuhiko, Yan, Zhen, Schiaffino, Stefano, Asahara, Hiroshi, Ushida, Takashi, Akimoto, Takayuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207415/
https://ncbi.nlm.nih.gov/pubmed/21926429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271270
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