Extra-long Gαs Variant XLαs Protein Escapes Activation-induced Subcellular Redistribution and Is Able to Provide Sustained Signaling

Murine models indicate that Gαs and its extra-long variant XLαs, both of which are derived from GNAS, markedly differ regarding their cellular actions, but these differences are unknown. Here we investigated activation-induced trafficking of Gαs and XLαs, using immunofluorescence microscopy, cell fr...

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Hauptverfasser: Liu, Zun, Turan, Serap, Wehbi, Vanessa L., Vilardaga, Jean-Pierre, Bastepe, Murat
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207409/
https://ncbi.nlm.nih.gov/pubmed/21890629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240150
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