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Paxillin Enables Attachment-independent Tyrosine Phosphorylation of Focal Adhesion Kinase and Transformation by RAS

Paxillin and HIC5 are closely related adapter proteins that regulate cell migration and are tyrosine-phosphorylated by focal adhesion kinase (FAK). Paxillin, HIC5, and FAK tyrosine phosphorylation increase upon cell attachment and decrease upon detachment from extracellular matrix. Unexpectedly, we...

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Библиографические подробности
Главные авторы: Wade, Ramon, Brimer, Nicole, Lyons, Charles, Pol, Scott Vande
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207406/
https://ncbi.nlm.nih.gov/pubmed/21900245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294504
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