ΔNp63α Protein Triggers Epithelial-Mesenchymal Transition and Confers Stem Cell Properties in Normal Human Keratinocytes

p63 is a p53 family protein required for morphogenesis and postnatal regeneration of epithelial tissues. Here we demonstrate that ΔNp63α, a p63 isoform lacking the N-terminal transactivation domain, induces epithelial-mesenchymal transition (EMT) in primary human keratinocytes in a TGF-β-dependent m...

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Detalhes bibliográficos
Main Authors: Oh, Ju-Eun, Kim, Reuben H., Shin, Ki-Hyuk, Park, No-Hee, Kang, Mo K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207403/
https://ncbi.nlm.nih.gov/pubmed/21880709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.244939
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