A Novel N,N-8-Amino-8-demethyl-d-riboflavin Dimethyltransferase (RosA) Catalyzing the Two Terminal Steps of Roseoflavin Biosynthesis in Streptomyces davawensis

Streptomyces davawensis synthesizes the antibiotic roseoflavin (RoF) (8-dimethylamino-8-demethyl-d-riboflavin). It was postulated that RoF is synthesized from riboflavin via 8-amino- (AF) and 8-methylamino-8-demethyl-d-riboflavin (MAF). In a cell-free extract of S. davawensis, an S-adenosyl methioni...

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Bibliographic Details
Main Authors: Jankowitsch, Frank, Kühm, Christian, Kellner, Roland, Kalinowski, Jörn, Pelzer, Stefan, Macheroux, Peter, Mack, Matthias
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207391/
https://ncbi.nlm.nih.gov/pubmed/21911488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292300
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