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Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

BACKGROUND: Alpha 2 (α(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (α(2)-adrenoceptor agonists) on...

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Detalhes bibliográficos
Main Authors: Gursoy, Sinan, Ozdemir, Ercan, Bagcivan, Ihsan, Altun, Ahmet, Durmus, Nedim
Formato: Artigo
Idioma:Inglês
Publicado em: Informa Healthcare 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207298/
https://ncbi.nlm.nih.gov/pubmed/21919812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03009734.2011.597889
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