Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

Assemblies of β-amyloid (Aβ) peptides are pathological mediators of Alzheimer's Disease (AD) and are produced by the sequential cleavages of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase. The generation of Aβ is coupled to neuronal activity, however the molecular basis...

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Main Authors: Wu, Jing, Petralia, Ronald S., Kurushima, Hideaki, Patel, Hiral, Jung, Mi-young, Volk, Lenora, Chowdhury, Shoaib, Shepherd, Jason D., Dehoff, Marlin, Li, Yueming, Kuhl, Dietmar, Huganir, Richard L., Price, Donald L., Scannevin, Robert, Troncoso, Juan C., Wong, Philip C., Worley, Paul F.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207263/
https://ncbi.nlm.nih.gov/pubmed/22036569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.036
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