Distinct Hydration Properties of Wild-Type and Familial Point Mutant A53T of α-Synuclein Associated with Parkinson's Disease

The propensity of α-synuclein to form amyloid plays an important role in Parkinson's disease. Three familial mutations, A30P, E46K, and A53T, correlate with Parkinson's disease. Therefore, unraveling the structural effects of these mutations has basic implications in understanding the mole...

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Détails bibliographiques
Auteurs principaux: Hazy, E., Bokor, M., Kalmar, L., Gelencser, A., Kamasa, P., Han, K.-H., Tompa, K., Tompa, P.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2011
Sujets:
Protein
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207174/
https://ncbi.nlm.nih.gov/pubmed/22067166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.08.052
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