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Behavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning

BACKGROUND: A major effect of low dose ethanol is impairment of hippocampus-dependent cognitive function. α4/δ-containing GABA(A)R’s are highly expressed within the dentate gyrus region of the hippocampus where they mediate a tonic inhibitory current that is sensitive to enhancement by low ethanol c...

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Main Authors: Cushman, Jesse D., Moore, Melissa D., Jacobs, Nate S., Olsen, Richard W., Fanselow, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207030/
https://ncbi.nlm.nih.gov/pubmed/21943327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2011.01546.x
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