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TLR2 agonist PSK activates human NK cells and enhances the anti-tumor effect of HER2-targeted monoclonal antibody therapy

PURPOSE: The therapeutic effect of trastuzumab monoclonal antibody (mAb) therapy has been shown to be partially dependent on functional NK cells. Novel agents that enhance NK cell function could potentially improve the anti-tumor effect of trastuzumab. We recently identified polysaccharide krestin (...

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Bibliografski detalji
Glavni autori: Lu, Hailing, Yang, Yi, Gad, Ekram, Inatsuka, Carol, Wenner, Cynthia A., Disis, Mary L., Standish, Leanna J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206987/
https://ncbi.nlm.nih.gov/pubmed/21918170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1142
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