Rad51 and BRCA2 - New Molecular Targets for Sensitizing Glioma Cells to Alkylating Anticancer Drugs

First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis. Alkylating agents target DNA, forming the killing les...

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Bibliographic Details
Main Authors: Quiros, Steve, Roos, Wynand Paul, Kaina, Bernd
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206939/
https://ncbi.nlm.nih.gov/pubmed/22073281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027183
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