Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

[Image: see text] The two-peptide lantibiotic haloduracin is composed of two post-translationally modified polycyclic peptides that synergistically act on Gram-positive bacteria. We show here that Halα inhibits the transglycosylation reaction catalyzed by PBP1b by binding in a 2:1 stoichiometry to i...

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Main Authors: Oman, Trent J., Lupoli, Tania J., Wang, Tsung-Shing Andrew, Kahne, Daniel, Walker, Suzanne, van der Donk, Wilfred A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2011
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206492/
https://ncbi.nlm.nih.gov/pubmed/22003874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja206281k
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