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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs possess a biological role in cancer cells that relies upon their ability to compete for microRNA binding and is ind...

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Autori principali: Poliseno, Laura, Salmena, Leonardo, Zhang, Jiangwen, Carver, Brett, Haveman, William J., Pandolfi, Pier Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206313/
https://ncbi.nlm.nih.gov/pubmed/20577206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09144
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