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RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis

The p19ARF tumor suppressor limits ribosome biogenesis and responds to hyperproliferative signals to activate the p53 checkpoint response. While its activation of p53 has been well characterized, ARF’s role in restraining nucleolar ribosome production is poorly understood. Here we report the use of...

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Autori principali: Saporita, Anthony J., Chang, Hsiang-Chun, Winkeler, Crystal L., Apicelli, Anthony J., Kladney, Raleigh D., Wang, Jianbo, Townsend, R. Reid, Michel, Loren S., Weber, Jason D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206203/
https://ncbi.nlm.nih.gov/pubmed/21937682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1472
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