Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas

We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor. We initially looked for unbalanced genomic rearrangements in the Sox2 locus in 42 GBM samples and found that Sox2...

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Detalhes bibliográficos
Main Authors: Alonso, Marta M., Diez-Valle, Ricardo, Manterola, Lorea, Rubio, Angel, Liu, Dan, Cortes-Santiago, Nahir, Urquiza, Leire, Jauregi, Patricia, de Munain, Adolfo Lopez, Sampron, Nicolás, Aramburu, Ander, Tejada-Solís, Sonia, Vicente, Carmen, Odero, María D., Bandrés, Eva, García-Foncillas, Jesús, Idoate, Miguel A., Lang, Frederick F., Fueyo, Juan, Gomez-Manzano, Candelaria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206066/
https://ncbi.nlm.nih.gov/pubmed/22069467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026740
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