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The Differential Role of Hif1β/Arnt and the Hypoxic Response in Adipose Function, Fibrosis, and Inflammation

In obesity, adipocytes distant from vasculature become hypoxic and dysfunctional. This hypoxic response is mediated by hypoxia inducible factors (Hif1α, Hif2α, and Hif3α), and their obligate partner Hif1β (Arnt). We show that mice lacking Hif1β in fat (FH1βKO) are lean, exhibit reduced adipocyte siz...

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Hlavní autoři: Lee, Kevin Y., Gesta, Stephane, Boucher, Jeremie, Wang, Xiaohui L., Kahn, C. Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206000/
https://ncbi.nlm.nih.gov/pubmed/21982709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.08.006
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