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Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism
The brain is the most cholesterol-rich organ in the body, most of which comes from in situ synthesis. Here we demonstrate that in insulin-deficient diabetic mice, there is a reduction in expression of the major transcriptional regulator of cholesterol metabolism, SREBP-2, and its downstream genes in...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205997/ https://ncbi.nlm.nih.gov/pubmed/21109190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.006 |
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