PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling

Activation of matrix metalloproteinase-9 (MMP-9) is involved in HIV-1-induced disruption of the blood-brain barrier (BBB). In the present study, we hypothesize that peroxisome proliferator-activated receptor (PPAR)-α or PPARγ can protect against HIV-1-induced MMP-9 overexpression in brain endothelia...

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Hlavní autoři: Huang, Wen, András, Ibolya E., Rha, Geun Bae, Hennig, Bernhard, Toborek, Michal
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2011
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205841/
https://ncbi.nlm.nih.gov/pubmed/21840940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-188607
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