Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription

Regulation of glucose homeostasis by insulin depends on pancreatic β-cell growth, survival, and function. Raf-1 kinase is a major downstream target of several growth factors that promote proliferation and survival of many cell types, including the pancreatic β cells. We have previously reported that...

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Hauptverfasser: Alejandro, Emilyn U., Lim, Gareth E., Mehran, Arya E., Hu, Xiaoke, Taghizadeh, Farnaz, Pelipeychenko, Dmytro, Baccarini, Manuela, Johnson, James D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2011
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205833/
https://ncbi.nlm.nih.gov/pubmed/21817126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-180349
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