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The Signaling and Transformation Potency of the Overexpressed HER2 Protein is Dependent on the Normally-Expressed EGFR
Human epidermal growth factor receptor 2 (HER2) belongs to the EGFR family of receptor tyrosine kinases that comprises four members. As opposed to the other family members, HER2 does not require ligand binding for activation. Hence, HER2 molecules can undergo spontaneous dimerization, autophosphoryl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205337/ https://ncbi.nlm.nih.gov/pubmed/21911055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.08.015 |
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