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HIGH-PERFORMANCE AFFINITY CHROMATOGRAPHY AND THE ANALYSIS OF DRUG INTERACTIONS WITH MODIFIED PROTEINS: BINDING OF GLICLAZIDE WITH GLYCATED HUMAN SERUM ALBUMIN

This study used high-performance affinity chromatography (HPAC) to examine the binding of gliclazide (i.e., a sulfonylurea drug used to treat diabetes) with the protein human serum albumin (HSA) at various stages of modification due to glycation. Frontal analysis conducted with small HPAC columns wa...

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Bibliografski detalji
Glavni autori: Matsuda, Ryan, Anguizola, Jeanethe, Joseph, K.S., Hage, David S.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205319/
https://ncbi.nlm.nih.gov/pubmed/21922305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-011-5382-8
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