ANALYSIS OF DRUG INTERACTIONS WITH MODIFIED PROTEINS BY HIGH-PERFORMANCE AFFINITY CHROMATOGRAPHY: BINDING OF GLIBENCLAMIDE TO NORMAL AND GLYCATED HUMAN SERUM ALBUMIN

High-performance affinity chromatography (HPAC) was used to examine the changes in binding that occur for the sulfonylurea drug glibenclamide with human serum albumin (HSA) at various stages of glycation for HSA. Frontal analysis on columns containing normal HSA or glycated HSA indicated glibenclami...

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Main Authors: Matsuda, Ryan, Anguizola, Jeanethe, Joseph, K.S., Hage, David S.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489001/
https://ncbi.nlm.nih.gov/pubmed/23092871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2012.09.091
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