Poly(ADP-ribose) Polymerase 1 Is Indispensable for Transforming Growth Factor-β Induced Smad3 Activation in Vascular Smooth Muscle Cell

BACKGROUND: Transforming growth factor type-β (TGF-β)/Smad pathway plays an essential role in vascular fibrosis. Reactive oxygen species (ROS) generation also mediates TGF-β signaling-induced vascular fibrosis, suggesting that some sort of interaction exists between Smad and redox pathways. However,...

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Autors principals: Huang, Dan, Wang, Yan, Wang, Lin, Zhang, Fengxiao, Deng, Shan, Wang, Rui, Zhang, Yun, Huang, Kai
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205050/
https://ncbi.nlm.nih.gov/pubmed/22073128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027123
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