Poly(ADP-Ribose) Polymerase 1 Promotes Oxidative-Stress-Induced Liver Cell Death via Suppressing Farnesoid X Receptor α

Farnesoid X receptor α (FXR) is highly expressed in the liver and regulates the expression of various genes involved in liver repair. In this study, we demonstrated that activated poly(ADP-ribose) polymerase 1 (PARP1) promoted hepatic cell death by inhibiting the expression of FXR-dependent hepatopr...

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Detalhes bibliográficos
Main Authors: Wang, Cheng, Zhang, Fengxiao, Wang, Lin, Zhang, Yanqing, Li, Xiangrao, Huang, Kun, Du, Meng, Liu, Fangmei, Huang, Shizheng, Guan, Youfei, Huang, Dan, Huang, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838191/
https://ncbi.nlm.nih.gov/pubmed/24043304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00160-13
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