Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

BACKGROUND: Despite its effectiveness in the treatment of various cancers, the use of doxorubicin is limited by a potentially fatal cardiomyopathy. Prevention of this cardiotoxicity remains a critical issue in clinical oncology. We hypothesized that flavaglines, a family of natural compounds that di...

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Main Authors: Bernard, Yohann, Ribeiro, Nigel, Thuaud, Frédéric, Türkeri, Gülen, Dirr, Ronan, Boulberdaa, Mounia, Nebigil, Canan G., Désaubry, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204970/
https://ncbi.nlm.nih.gov/pubmed/22065986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025302
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