Fused has evolved divergent roles in vertebrate Hedgehog signaling and motile ciliogenesis

Hedgehog (Hh) signaling is essential for multiple aspects of embryogenesis1, 2. In Drosophila, Hh transduction is mediated by a cytoplasmic signaling complex3-5 that includes the putative serinethreonine kinase Fused (Fu) and the kinesin Costal 2 (Cos2), yet Fu does not play a conserved role in Hh s...

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Bibliographic Details
Main Authors: Wilson, Christopher W., Nguyen, Catherine T., Chen, Miao-Hsueh, Yang, Jehn-Hsiahn, Gacayan, Rhodora, Huang, Jie, Chen, Jau-Nian, Chuang, Pao-Tien
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204898/
https://ncbi.nlm.nih.gov/pubmed/19305393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07883
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