Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition

Mutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA). SLC26A4 encodes pendrin, an anion-base exchanger expressed in inner ear epithelial cells that secretes HCO(3)(–) into endolymph. Studies of Slc26a4-null mice indicate that pendrin is es...

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Detalhes bibliográficos
Main Authors: Choi, Byung Yoon, Kim, Hyoung-Mi, Ito, Taku, Lee, Kyu-Yup, Li, Xiangming, Monahan, Kelly, Wen, Yaqing, Wilson, Elizabeth, Kurima, Kiyoto, Saunders, Thomas L., Petralia, Ronald S., Wangemann, Philine, Friedman, Thomas B., Griffith, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204851/
https://ncbi.nlm.nih.gov/pubmed/21965328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59353
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