Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Pulmonary hypertension is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Several growth factors, including EGF, PDGF, and TGF-β1, are involved in pulmonary vascular remodeling during pulmonary hypertension. However, increased knowledge of the downstream si...

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Autores principales: Ma, Wanli, Han, Weihong, Greer, Peter A., Tuder, Rubin M., Toque, Haroldo A., Wang, Kevin K.W., Caldwell, R. William, Su, Yunchao
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204840/
https://ncbi.nlm.nih.gov/pubmed/22005303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57734
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