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Synthesis and reactions of a nucleoside derivative of phosphoric sulfonic anhydride. Studies related to the mechanisms of coupling reactions in the chemical synthesis of oligodeoxyribonucleotides by phosphotriester procedures.

The synthesis of a model compound, diphenylphosphoric toluene-p-sulfonic anhydride, an arylsubstituted phosphoric sulfonic mixed anhydride, is described. Using the same procedure a thymidyl substituted derivative was prepared. The phosphoric sulfonic anhydride is the presumed intermediate in oligonu...

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Main Authors: Dabkowski, W, Skrzypczynski, Z, Michalski, J, Piel, N, McLaughlin, L W, Cramer, F
Format: Artigo
Jezik:Inglês
Izdano: 1984
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC320442/
https://ncbi.nlm.nih.gov/pubmed/6549065
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