ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but many eventually become estrogen-independent and recur. We identified an estrogen-independent role for ER and the CDK4/Rb/E2F transcriptional axis in the hormone-independent growth of breast cancer cells. ER...

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Autors principals: Miller, Todd W., Balko, Justin M., Fox, Emily M., Ghazoui, Zara, Dunbier, Anita, Anderson, Helen, Dowsett, Mitch, Jiang, Aixiang, Smith, R. Adam, Maira, Sauveur-Michel, Manning, H. Charles, González-Angulo, Ana M., Mills, Gordon B., Higham, Catherine, Chanthaphaychith, Siprachanh, Kuba, Maria G., Miller, William R., Shyr, Yu, Arteaga, Carlos L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204388/
https://ncbi.nlm.nih.gov/pubmed/22049316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0101
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