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A Pathogenic Linked Mutation in the Catalytic Core of Human Cystathionine β-synthase Disrupts Allosteric Regulation and Allows Kinetic Characterization of a Full-length Dimer()
Cystathionine β-synthase catalyzes the condensation of serine and homocysteine to yield cystathionine and is the single most common locus of mutations associated with homocystinuria. In this study, we have examined the kinetic consequences of a pair of linked patient mutations, P78R/K102N, that are...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204387/ https://ncbi.nlm.nih.gov/pubmed/17352495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602617f |
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