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HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by gp120-specific siRNA and inhibitors of NF-kappa B pathway
HIV associated neurological disorders (HAND) is a common neurological complication in patients infected with HIV. The proinflammatory cytokines and chemokines produced by astrocytes play a pivotal role in neuroinflammatory processes in the brain and viral envelope gp120 has been implicated in this p...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204359/ https://ncbi.nlm.nih.gov/pubmed/21945445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.09.033 |
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