Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

BACKGROUND: Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic receptors (NMDAR). At the molecular level, it has been...

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Autores principales: Jullienne, Amandine, Montagne, Axel, Orset, Cyrille, Lesept, Flavie, Jane, David E, Monaghan, Daniel T, Maubert, Eric, Vivien, Denis, Ali, Carine
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204249/
https://ncbi.nlm.nih.gov/pubmed/21975018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-68
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