Dual inhibition of SRC and Aurora kinases induces post-mitotic attachment defects and cell death

Increased activity of SRC family kinases promotes tumor invasion and metastasis, and overexpression of the mitotic regulator Aurora kinase A (AURKA) drives tumor aneuploidy and chromosomal instability. These actions nominate SRC and AURKA as valuable therapeutic targets for cancer, and inhibitors fo...

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Autors principals: Ratushny, Vladimir, Pathak, Harsh B, Beeharry, Neil, Tikhmyanova, Nadezhda, Xiao, Fang, Li, Tianyu, Litwin, Samuel, Connolly, Denise C., Yen, Timothy J., Weiner, Louis M., Godwin, Andrew K., Golemis, Erica A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204164/
https://ncbi.nlm.nih.gov/pubmed/21785464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.314
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