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Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-Spectrum Antiproliferative Activities
Histone deacetylase (HDAC) inhibitors have emerged as a new class of anticancer drugs, with one synthetic compound, SAHA (vorinostat, Zolinza(®); 1), and one natural product, FK228 (depsipeptide, romidepsin, Istodax(®); 2), approved by FDA for clinical use. Our studies of FK228 biosynthesis in Chrom...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204160/ https://ncbi.nlm.nih.gov/pubmed/21793558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200324x |
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