Collagen Type II and a Thermo-Responsive Polymer of N-Isopropylacrylamide Induce Arthritis Independent of Toll-Like Receptors: A Strong Influence by Major Histocompatibility Complex Class II and Ncf1 Genes

We established and characterized an arthritis mouse model using collagen type II (CII) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNiPAAm). The new PNiPAAm adjuvant is TLR-independent, as all immunized TLR including MyD88-deficient mice developed an anti-CII response. Unlike other...

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Detalhes bibliográficos
Main Authors: Shakya, Akhilesh Kumar, Kumar, Ashok, Klaczkowska, Dorota, Hultqvist, Malin, Hagenow, Kristin, Holmdahl, Rikard, Nandakumar, Kutty Selva
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204090/
https://ncbi.nlm.nih.gov/pubmed/21933654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.034
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