Substance P Induces CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells

We have shown that substance P (SP) and its neurokinin-1 receptor (NK-1R) regulate intestinal angiogenesis by increasing expression of protein CYR61 (the cysteine-rich angiogenic inducer 61, or CCN1) in colonic epithelial cells. However, the mechanism involved in SP-induced CCN1 expression has not b...

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Detalhes bibliográficos
Main Authors: Koon, Hon Wai, Shih, David Q., Hing, Tressia C., Chen, Jeremy, Ho, Samantha, Zhao, Dezheng, Targan, Stephan R., Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204086/
https://ncbi.nlm.nih.gov/pubmed/21945803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.038
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