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The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH

The hypoxia-inducible factor (HIF) is a master regulator of the cellular response to hypoxia. Its levels and activity are controlled by dioxygenases called prolyl-hydroxylases and factor inhibiting HIF (FIH). To activate genes, HIF has to access sequences in DNA that are integrated in chromatin. It...

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Hlavní autoři: Melvin, Andrew, Mudie, Sharon, Rocha, Sonia
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204077/
https://ncbi.nlm.nih.gov/pubmed/21900490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-02-0163
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