Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway

Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ) signaling, leading to cell growth advantage. Halofuginone (HF), a low-molecular-weight alkaloid that modulates TGFβ signaling, was used to tr...

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Detalhes bibliográficos
Main Authors: de Figueiredo-Pontes, Lorena L., Assis, Patricia A., Santana-Lemos, Bárbara A. A., Jácomo, Rafael H., Lima, Ana Sílvia G., Garcia, Aglair B., Thomé, Carolina H., Araújo, Amélia G., Panepucci, Rodrigo A., Zago, Marco A., Nagler, Arnon, Falcão, Roberto P., Rego, Eduardo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203897/
https://ncbi.nlm.nih.gov/pubmed/22053203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026713
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