Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood–brain water uptake and confers barrier function on perivascular astrocyte endfeet

Tissue- and cell-specific deletion of the Aqp4 gene is required to differentiate between the numerous pools of aquaporin-4 (AQP4) water channels. A glial-conditional Aqp4 knockout mouse line was generated to resolve whether astroglial AQP4 controls water exchange across the blood–brain interface. Th...

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Main Authors: Haj-Yasein, Nadia Nabil, Vindedal, Gry Fluge, Eilert-Olsen, Martine, Gundersen, Georg Andreas, Skare, Øivind, Laake, Petter, Klungland, Arne, Thorén, Anna Elisabeth, Burkhardt, John Michael, Ottersen, Ole Petter, Nagelhus, Erlend Arnulf
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203818/
https://ncbi.nlm.nih.gov/pubmed/21990350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110655108
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