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Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water c...

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Publicado en:Mol Cell Neurosci
Autores principales: Vindedal, Gry Fluge, Thoren, Anna E., Jensen, Vidar, Klungland, Arne, Zhang, Yong, Holtzman, Michael J., Ottersen, Ole Petter, Nagelhus, Erlend A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157926/
https://ncbi.nlm.nih.gov/pubmed/27751903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2016.10.004
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