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Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states
We applied single-molecule photobleaching to investigate the stoichiometry of human Orai1 and Orai3 channels tagged with eGFP and expressed in mammalian cells. Orai1 was detected predominantly as dimers under resting conditions and as tetramers when coexpressed with C-STIM1 to activate Ca(2+) influx...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203769/ https://ncbi.nlm.nih.gov/pubmed/21987805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114814108 |
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